The crash happened just north of Elmerton Avenue around 6:15 p.m., police detailed in the release.
Responding officers found a severely injured child at the scene. The child was transported to a local hospital, where they later succumbed to their injuries.
The Harrisburg Police Traffic Safety Unit arrived to investigate, and the road remained closed for several hours during their investigation and cleanup.
This investigation is ongoing. Check back for updates as more information becomes available.
Police are asking anyone who witnessed the crash or has information to contact them at 717-558-6900.
Click here to follow Daily Voice Myerstown and receive free news updates.